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Literature summary extracted from

  • Lin, S.; Choe, J.; Du, P.; Triboulet, R.; Gregory, R.I.
    The m(6)A methyltransferase METTL3 promotes translation in human cancer cells (2016), Mol. Cell, 62, 335-345 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.1.1.348 medicine METTL3 expression is elevated in lung adenocarcinoma and promotes growth, survival, and invasion of human lung cancer cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.348 D395A/A398A catalytically inactive Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.348 ribosome
-
 Homo sapiens 5840
-
2.1.1.348 ribosome METTL3 associates with ribosomes Homo sapiens 5840
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.348 S-adenosyl-L-methionine + adenine in RNA Homo sapiens
-
 S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.348 Homo sapiens Q86U44
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.348 A-549 cell
-
 Homo sapiens
-
2.1.1.348 H-1299 cell
-
 Homo sapiens
-
2.1.1.348 HeLa cell
-
 Homo sapiens
-
2.1.1.348 lung adenocarcinoma cell
-
 Homo sapiens
-
2.1.1.348 NCI-H1299 cell
-
 Homo sapiens
-
2.1.1.348 NCI-H1792 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.348 S-adenosyl-L-methionine + adenine in RNA
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.348 METTL3
-
 Homo sapiens
2.1.1.348 RNA m6A methyltransferase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.1.1.348 physiological function METTL3 associates with ribosomes and promotes translation in the cytoplasm. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to a reporter mRNA. METTL3 enhances mRNA translation through an interaction with the translation initiation machinery Homo sapiens
2.1.1.348 physiological function the enzyme promotes translation of certain mRNAs including epidermal growth factor receptor and the Hippo pathway effector TAZ in human cancer cells. The enzyme enhances translation of target mRNAs by recruiting eIF3 to the translation initiation complex. The enzyme promotes growth, survival, and invasion of human lung cancer cells Homo sapiens